Product name: Pseudin-2

Sequence: GLNALKKVFQGIHEAIKLINNHVQ

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Pseudin-2, an AMP isolated from the skin of the South American paradoxical frog Pseudis paradoxa.We found that pseudin-2 organized to an aggregated state in aqueous solution, but that it dissociated into monomers upon binding to lipopolysaccharide (LPS), even though it did not neutralize LPS in Gram-negative bacteria. In addition, pseudin-2 assumed an α-helical structure in the presence of biological membranes and formed pores in both bacterial and fungal membranes, through which it entered the cytoplasm and tightly bound to RNA.

Uniprot ID: P83189

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1808, Issue 1, January 2011, Pages 171-182.

Regulatory Peptides, Volume 129, Issues 1–3, 15 July 2005, Pages 85-91.

Biochemical and Biophysical Research Communications, Volume 288, Issue 4, 9 November 2001, Pages 1001-1005.