Product name: GRR10W4N

Sequence: GRRPRPRPRPWWWW-NH2

Modifications: c-terminal amide,

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: End-tagging with oligotryptophan promotes peptide-induced lysis of phospholipid liposomes, as well as membrane rupture and killing of bacteria and fungi. This antimicrobial potency is accompanied by limited toxicity for human epithelial cells and low hemolysis. The functional selectivity displayed correlates to a pronounced selectivity of such peptides for anionic lipid membranes, combined with a markedly reduced membrane activity in the presence of cholesterol. GRR10W4N potently induces leakage in liposomes at both high and low ionic strength, whereas the non-tagged GRR10 and GRR10N display very limited liposome

leakage induction. GRR10W4N displays potent antimicrobial effects against S. aureus, which exceed those of omiganan and LL-37, while for P. aeruginosa, antimicrobial effects

for GRR10W4N and LL-37 are comparable, and significantly stronger than that of omiganan.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Biochimica et Biophysica Acta. 1808 (2011) 1081–1091.