Product
name: FAR
Sequence: FAR
Purity: 95% by
HPLC
Counter
ion: Trifluoacetate
Format: Lyophilized
powder
Description: Cationic AMPs are important
candidates for anti-fungal therapeutic agents due to broad spectra of
anti-microbial activity. The presence of Phe in these peptides suggests that it
plays a critical role in anti-microbial activities. revious studies showed that
peptides containing hydrophobic, positively charged residues like Arg, Lys are
effective AMP and Phe serve as a membrane anchor in immunogenic. Very few small
(tripeptide) AMPs are known so far. One tripeptide, GHK, was reported to inhibit
the growth of Escherichi coli. 3-bromocoumarins and 2-methylimidazoles analogues
of di-, tri-, tetra-peptides were found to exhibit anti-microbial activity. It
has also been reported that conjugation of a palmitic acid to the N-terminus of
very short cationic di- and tripeptide further provided them with potent
anti-microbial activities.The phenylalanine (Phe) in peptide has great
importance for providing anti-microbial activity. An AMP named prophenin is rich
in Pro and Phe and exhibits activity against the Gram-negative
bacteria.Moreover, molecular dynamics has shown that Phe plays a crucial role in
the membrane permeabiliation.In this study five tripeptide were synthesized
containing Phe with different combination of cationic and aliphatic amino acids
to have efficient anti-fungal properties. The cationic peptides with hydrophobic
residues deeply penetrate the membrane of the microbes.The Arg and Trp make the
peptide more anti-microbial in nature. Arg endowed the peptide with cationic
property and hydrogen bonding, which is very crucial for interaction with
anionic component of the fungal membrane. The small peptides are
non-immunogenic. Keeping these fundamental things in mind, we have designed and
synthesized tripeptide with different combinations and found that FAR was
showing better anti-fungal effect than other four peptides. FAR is the first
tripeptide has anti-fungal activity by inhibiting the growth of C.
krusei.
Usage: For
Scientific Research Use Only, Not for Human Use.
Reference:
Indian J Med
Microbiol. 2015 Jan-Mar;33(1):110-6.