Sequence: GQSQWRDVCRNFMRR

Modifications: dimer,interchain disulfide,

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: G15 corresponding to the residues 37–51 of granulysin was synthesized by substituting both the arginine residues (Arg-38 and Arg-40) with glutamine residues. The G15 peptide has been shown to exhibit reduced lytic activity against bacteria and human Jurkat cells. As such, the G15 peptide monomer has 3 cationic charges and shows neither antimicrobial nor antitumor activities. However, under non-reducing conditions, the peptide undergoes dimerization through intermolecular S–S linkage resulting in a 30-residue G15 peptide with 6 cationic charges. A 15-residue peptide dimer G15 derived from the cell lytic protein granulysin has been shown to exert potent activity against microbes, including E. coli, but not against human Jurkat cells.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Biochimica et Biophysica Acta (BBA) - Biomembranes.Volume 1758, Issue 2, February 2006, Pages 154–163.