Product name: FHV coat (35–49)

Synonyms: Flock House Virus-derived Peptide,flock house virus (FHV) coat (35–49) peptide,FHV peptide,

Sequence: RRRRNRTRRNRRRVR

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: A peptide derived from the flock house virus (FHV) coat protein was internalized most efficiently into Chinese hamster ovary (CHO-K1), HeLa, and Jurkat cells.Comparison of the factors facilitating the internalization with those of the Tat peptide revealed that the FHV peptide induces macropinocytosis much more efficiently than the Tat peptide, which leads to its high cellular uptake efficiency. Additionally, the strong adsorption of the FHV peptide on cell membranes via glycosaminoglycans (GAGs) was shown to be a key factor for induction of macropinocytosis, and these steps were successfully monitored by live imaging of the peptide internalization into cells in relation to the actin organization. The remarkable methods of FHV peptide internalization thus highlighted the critical factors for internalizations of the arginine-rich CPPs.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

J Biol Chem,2001, 276: 5836–5840.