Product name: Synthetic XIP (sXIP)

Synonyms: ComS(11–17) peptide,competence-inducing peptide (CIP),
 XIP (sigX-inducing peptide),

Sequence: GLDWWSL

Purity: 95% by HPLC

Counter ion: Trifluoroacetate

Format: Lyophilized powder

Description: Synthetic XIP (sXIP) (amino acid sequence, GLDWWSL), corresponding to residues 11 to 17 of ComS.Providing S. mutans with synthetic fragments of CIP revealed that seven C-terminal residues, including the WW motif, cause robust induction of both sigX and the competent state.ComS11–17 was unable to rescue the transformation-deficient phenotype of the comR deletion, supporting the hypothesis that the competence-inducing properties of ComS are propagated through ComR.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

J Bacteriol. 2014 Jan;196(2):227-36.

FEMS Microbiol Lett. 2012 Nov; 336(2):104-12.

J Bacteriol. 2012 Aug;194(15):3781-8.

Mol Microbiol. 2010 Nov;78(3):589-606.