Product name: AVGIGA

Synonyms: anti-gp41 hexapeptide,

Sequence: AVGIGA

Purity: 95% by HPLC

Counter ion: Trifluoroacetate

Format: Lyophilized powder

Description: Owens and coworkers demonstrated the capacity of AVGIGA hexapeptide, identical in amino acid sequence to the gp41 N-terminus, to completely inhibit syncitium formation mediated by HIV-1 envelope glycoproteins expressed at the surface of HeLa CD4+ cells, an observation that has been reproduced in the present work. The inhibitory effect was sequence-specific and dose-dependent. These authors suggested that the inhibitors might interact with its homologous FP sequence at gp41 thereby preventing its normal fusogenic function. This suggestion was supported by later studies in model membranes by Pereira et al. which revealed that N-terminal AVGIGA hexapeptide also interfered with FP-vesicle interaction.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

FEBS Letters.Volume 580, Issue 11, 15 May 2006, Pages 2561–2566.

AIDS Res. Hum. Retroviruses, 13 (1997), pp. 1203–1211.

Retroviruses, 6 (1990), pp. 1289–1296.