Product name: Ala-Glu-Asp-Gly

Synonyms: AE-0 peptide ,AEDG,Epitalon, Epithalon, alanyl-glutamyl-aspartyl-glycine,(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid,

Sequence: Ala-Glu-Asp-Gly

Purity: 95% by HPLC

Format: White powder

Description: It has been revealed that epithalamin (polipeptide preparation from bovine brain) and its active fragment, epitalon (Ala-Glu-Asp-Gly) along with their ability to stimulate melatonin production, have an antioxidant mechanism that is quite different from the action of melatonin.Epitalon significantly increased the lifespan (LS) of imagoes by 11-16% when applied at unprecedented low concentrations-from 0.001 x 10(-6) to 5 x 10(-6) wt.% of culture medium for males and from 0.01 x 10(-6) to 0.1 x 10(-6) wt.% of culture medium for females. The increase in LS did not depend on the substance dose. Effective concentrations of epitalon were 16,000-80,000,000 times lower than those of melatonin.Epitalon inhibited also the development of tumors in jejunum and ileum.Epithalamin and synthetic tetrapeptide Epitalon (Ala–Glu–Asp–Gly) are potent inhibitors of mammary carcinogenesis in rodents and might be useful in the prevention of breast cancer in women at risk.

Compound ID: 219042

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Archives of Gerontology and Geriatrics.Volume 44, Supplement, 2007, Pages 213–216.

Neuro Endocrinol Lett. 2002; 23 Suppl 3:11-144.

Cancer Letters, Volume 183, Issue 1, 8 September 2002, Pages 1-8.

Adv. Gerontol. 2000;4:88–96.

Mech Ageing Dev. 2000 Dec 1;120(1-3):141-9.