Product name: Neuromedin U(NmU)

Organism: Human

Synonyms: Neuromedin U-25,

Sequence: FRVDEEFQSPFASQSRGYFLFRPRN

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Neuromedin U (NmU) belongs to the neuromedin family, comprising a series of neuropeptides involved in the gut-brain axis and including neuromedins B and C (bombesin-like), K (neurokinin B), L (neurokinin A or neurotensin), N, S, and U.Neuromedin U (NMU) are bioactive peptides with a common C-terminal heptapeptide sequence (FLFRPRN-amide) among mammals, which is responsible for receptor activation, namely NMU receptor types 1 (NMUR1) and 2 (NMUR2). NmU as a candidate drug response biomarker for HER2-overexpressing cancers and as a candidate therapeutic target to limit metastatic progression and improve the efficacy of HER-targeted drugs. Neuromedin U (NMU) is a 25 amino acid peptide expressed and secreted in the brain and gastrointestinal tract. Data have shown that peripheral administration of human NMU decreases food intake and body weight and improves glucose tolerance in mice, suggesting that NMU receptors constitute a possible anti-diabetic and anti-obesity drug target.

Uniprot ID: P48645

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Clin Chem. 2015 Jan 20. pii: clinchem.2014.231753.

J. Med. Chem., 2014, 57 (15), pp 6583–6593.

Regul Pept. 2014 Jun-Aug;192-193:24-9.

Cancer Res. 2014 Jul 15;74(14):3821-33.

J Neuroendocrinol. 2013 Dec;25(12):1264-72.

Nat Med. 2007 Oct; 13(10):1234-40.

Pharmacol Rev. 2004 Jun; 56(2):231-48.