Product name: Livagen

Synonyms: Lys-Glu-Asp-Ala

Sequence: Lys-Glu-Asp-Ala

Purity: 95% by HPLC

Format: White powder

Description: Livagen induced activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin, and release of genes repressed due to age-related condensation of euchromatic regions in chromosomes. Our results indicate that Livagen causes de-heterochromatinization (activation) of chromatin, which is realized via modification of heterochromatin and heterochromatinized regions in chromosomes from old people.Livagen proved to be more efficient also as compared to well-known peptidase inhibitors such as puromycin, leupeptin, and D-PAM. The dose-inhibitory effect curves for Livagen and Epitalon were plotted; their IC50 equaled 20 and 500 microM, respectively.
It is stated that Livagen (Lys-Glu-Asp-Ala) is a weakly hydrolyzed peptide. Peptide hydrolases of small intestine do not hydrolyze Livagen even to a small extent. Under in vitro conditions Livagen reduces glycil-L-leucinedipeptidase activity in small intestine by 50%.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Bull Exp Biol Med. 2013 Mar;154(5):681-5.

Bull Exp Biol Med. 2011 Feb;150(4):495-9.

Adv Gerontol. 2011;24(1):93-8.

Patol Fiziol Eksp Ter. 2010 Jan-Mar;(1):14-8.