Product name: antioxidant tetrapeptide UPF1

Synonyms: 4-methoxy-l-tyrosinyl-γ-l-glutamyl-l-cysteinyl-glycine,

Sequence: Tyr(Me)-γ-Glu-Cys-Gly

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: UPF1, a tetrapeptide GSH analogue, 4-methoxy-l-tyrosinyl-γ-l-glutamyl-l-cysteinyl-glycine, known to possess a 50-fold higher hydroxyl radical scavenging efficiency than does GSH, normalized the intracellular GSH level in the human bronchial epithelial cells under oxidative stress caused by CSC. UPF1 restored the GCLM and GSH reductase mRNA levels, which were significantly augmented by CSC treatment, back to the level of untreated control cells, referring to a successful establishment of control by UPF1 upon the over-accumulation of GSH. Moreover, UPF1 showed a significantly more potent antioxidant capacity than did N-acetyl-l-cysteine (NAC) and, compared to NAC, demonstrated a better potential to assure the whole GSH homeostasis in human bronchial epithelial cells. 

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Experimental and Toxicologic Pathology. Volume 65, Issue 6, September 2013, Pages 711–717.