Product name: Ala-Ser-Leu

Synonyms: ACE-inhibiting peptide,

Sequence: Ala-Ser-Leu

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: A novel ACE inhibitory peptide, Ala-Ser-Leu, with the IC50 value of 102.15 μM, was identified by IT-MS/MS. This is the first report of Ala-Ser-Leu from natural protein. Lineweaver–Burk plots suggest that the peptide is a competitive inhibitor against ACE. The molecular docking studies revealed that the ACE inhibition of Ala-Ser-Leu is mainly attributed to forming very strong hydrogen bonds with the S1 pocket (Ala354) and the S2 pocket (Gln281 and His353). The results indicate that silkworm pupa (B. mori) protein or its gastrointestinal protease hydrolysate could be used as a functional ingredient in auxiliary therapeutic foods against hypertension.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Peptides. Volume 68, June 2015, Pages 17–24.