Product name: d-peptide D3

Synonyms: d-enantiomeric peptide D3,

Sequence: rprtrlhthrnr

Purity: 95% by HPLC

Counter ion: Trifluoroacetate

Format: Lyophilized powder

Description: The d-peptide D3 (amino acid sequence RPRTRLHTHRNR), β-sheet breaking d-enantiomeric dipeptide was reported to selectively target Aβ soluble oligomers, was identified during a mirror image phage display selection using d-enantiomeric Aβ42 as a target under conditions where monomeric or small oligomeric Aβ42 species can be expected to be the dominating species. The compound was orally bioavailable, reduced the plaque load in AD transgenic mice, and improved their cognitive performance. D3 precipitates toxic Aβ species and converts them into nonamyloidogenic, nonfibrillar, and nontoxic aggregates without increasing the concentration of monomeric Aβ. Thus, D3 exerts an interesting and novel mechanism of action that abolishes toxic Aβ oligomers and thereby supports their decisive role in AD development and progression.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

ACS Chem Neurosci. 2010 Sep 15;1(9):639-48.

J Alzheimers Dis. 2013; 34(3):609-20.

ChemMedChem. 2008 Dec; 3(12):1848-52.