Product name: Biphalin

Synonyms: Bis(tyr-ala-gly-phenh2)hydrazide, D-Enk-O, Dala(2), D-ENK,enkephalin dimer,

Sequence:  (Tyr-D-Ala-Gly-Phe-NH-)2

Modifications:

M.W: C46H56N10O10

M.F.: 909.0

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Biphalin is an octapeptide consisting of two monomers of a modified enkephalin, attached via a hydrazine bridge, and with the amino acids assembled in a palindromic sequence. Dimeric opioid peptide biphalin presents a unique structure based on two enkephalin-like branch (H-Tyr-d-Ala-Gly-Phe) linked by a hydrazine moiety. Its noticeable bioactivity is due to the peculiar structure, which has the ability to match the topographical requirements for both μ and δ opioid receptors. Furthermore, this opioid octapeptide induces less physical dependence and toxicities than other opioids.

Compound ID: 5487663

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

ACS Med Chem Lett. 2014 Sep 11; 5(9): 1032–1036.

Mini-Rev. Med. Chem. 2013, 13, 11–33.

J. Med. Chem. 2001, 44, 2259–2269.

Peptides 1982, 3, 697–700.