Product name: Rotigaptide

Synonyms: ZP 123,ZP123,ZP123 peptide

Sequence: Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2

Purity: 95% by HPLC

Format: White powder

Description: Rotigaptide is an antiarrhythmic peptide that improves cardiac conduction by modifying gap-junction communication. To address cardiac arrhythmia, hexa-peptides such as AAP10 derived from bovine atria and a stable analogue ZP123, now termed rotigaptide, have been developed to modify gap junctional channel properties and intercellular communication . Rotigaptide promoted electrical coupling between ventricular myocytes without changing membrane conductance . The peptide attenuated gap junction closure and preserved intercellular coupling during acidosis . Most importantly, rotigaptide reduced the inducibility of re-entry ventricular tachycardia during acute ischaemia in dogs . Indeed, these properties suggest that rotigaptide could be a prototype of a new class of antiarrhythmic drug.

Compound ID: 9938933

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Heart Rhythm. 2015 Jul 15. pii: S1547-5271(15)00905-4.

Arch Med Sci. 2014 May 12;10(2):374-80.

Circ Arrhythm Electrophysiol. 2011 Jun;4(3):344-51.

Biochem Pharmacol. 2008 Nov 15;76(10):1194-200.

Br J Pharmacol. 2006 Mar; 147(5):486-95.