Product name: Linaclotide

Synonyms: MD-1100,

Sequence: CCEYCCNPACTGCY

Modifications: Disulfide(1-6,2-10,5-13)

Purity: 95% by HPLC

Counter ion: Acetate

Format: Lyophilized powder

Description: Linaclotide, a 14-amino acid synthetic peptide, is a first-in-class, high-affinity guanylate cyclase C agonist (GCCA)  that is homologous to the paracrine peptide hormones guanylin and uroguanylin, i.e. the endogenous activators of guanylate cyclase C (GC-C).Linaclotide has been shown to be stable under in vitro conditions mimicking the gastric environment, i.e. exposure to a highly acidic pH and gastric hydrolases. After oral administration, linaclotide is metabolised in the small intestine to an active metabolite, a 13-amino acid peptide that retains linaclotide's pharmacological activity.

Compound ID: 16158208

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Drugs. 2014 Jan;74(1):53-60.

Prescrire Int. 2014 Dec;23(155):285-8.

Biopolymers. 2011;96(1):69-80.

Gastroenterology. 2010 Mar; 138(3):813-7.