Product name: Gastrin-releasing peptide(GRP)

Organism: Human

Synonyms: GRP,

Sequence: VPLPAGGGTVLTKMYPRGNHWAVGHLM

Modifications: c-terminal amide

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin. GRP acts by binding to the GRP receptor (GRPR, also called BB2), a member of the G-protein coupled receptor (GPCR) superfamily. GRP produced by neurons in the central nervous system (CNS) plays a role in synaptic transmission by activating GRPRs located on postsynaptic membranes, influencing several aspects of brain function. It has been shown to exhibit mitogenic activity in small cell lung cancer and plays a role in a lot of other human cancers including tumors in colon, stomach, pancreas, breast, and prostate.

Uniprot ID: P07492

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Neurobiology of Learning and Memory. Volume 112, July 2014, Pages 44–52.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1766, Issue 1, August 2006, Pages 23-41.

Biochemical and Biophysical Research Communications, Volume 350, Issue 1, 10 November 2006, Pages 120-124

Human Pathology, Volume 43, Issue 12, December 2012, Pages 2342-2347.

PAIN®, Volume 155, Issue 1, January 2014, Pages 80-92.