Product name: Hemiasterlin

Synonym: Hemiasterlins A, (E,4S)-4-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-3-methyl-2-(methylamino)butanoyl]amino]-3,3-dimethylbutanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid,

Purity: 90% by HPLC

Compound ID: 5352091

Description: Hemiasterlin is a linear tripeptide isolated from the sponge Hemiasterella minor in 1994. It contains two unique amino acids and exhibited strong cytotoxic activity on the P388 leukaemia cell line. Hemiasterlin is a potent inhibitor of cell growth that, like vinblastine, depolymerizes microtubules and arrests cells in the G2-M phase of the cell cycle. However, like other peptide-like antimicrotubule agents, such as dolastatin-10 and cryptophycin-1, hemiasterlin noncompetitively inhibits the binding of vinblastine to tubulin. Because hemiasterlin competitively inhibits the binding of dolastatin-10 to tubulin, it has been proposed that these molecules bind to the Vinca-peptide-binding site of tubulin.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Cancer Res. 2003 Apr 15; 63(8):1838-45.

Cancer Chemother Pharmacol. 1997; 39(3):223-6.

Tetrahedron Lett. 1994;35:4453–4456.