Product name: HTI-286

Synonym: SPA110, N,β,β-trimethyl-L-phenylalanyl-N1-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]-N1,3-dimethyl-L-valinamide,

Purity: 90% by HPLC

Description: HTI-286, a hemiasterlin analogue, is an antimicrotubule agent that retains potency in cellular models resistant to several chemotherapeutics, including taxanes and Vinca alkaloids. The agent, formulated only in saline and given i.v. or p.o., inhibits the growth of human tumors in xenograft models that are either sensitive or resistant to currently approved antimicrotubule drugs.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Cancer Res April 15, 2003 63; 1838.

 J Nat Prod. 2003 Feb;66(2):183-99.