Product name: Chaxapeptin 1

Purity: 95% by HPLC

Sequence: GFGSKPLDSFGLNFF

Modifications: Lactone between N-terminal Gly and side chain COOH of Asp(8),

Description: Lasso peptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) that possess a unique “lariat knot” structural motif. Genome mining-targeted discovery of new natural products from microbes obtained from extreme environments has led to the identification of a gene cluster directing the biosynthesis of a new lasso peptide, designated as chaxapeptin 1, in the genome of Streptomyces leeuwenhoekii strain C58 isolated from the Atacama Desert. Subsequently, 1 was isolated and characterized using high-resolution electrospray ionization mass spectrometry and nuclear magnetic resonance methods. The lasso nature of 1 was confirmed by calculating its nuclear Overhauser effect restraint-based solution structure. Chaxapeptin 1 displayed a significant inhibitory activity in a cell invasion assay with human lung cancer cell line A549.

 Usage: For Scientific Research Use Only, Not for Human Use.

 Reference:

J. Org. Chem., 2015, 80 (20), pp 10252–10260.