Sequence:

H-D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH₂
(Disulfide bond)

Family Description:


This cyclic somatostatin agonist shows a high binding affinity for the somatostatin receptor (SSTR) subtype 2 and has a 10-fold less affinity for receptor subtype 5. It is also a potent inhibitor of growth hormone secretion from pituitary cells. Furthermore, the octapeptide exhibits a direct antiproliferative effect in vivo and in vitro on the growth of cells or solid tumors from a human small cell lung carcinoma.