Product name: Vasonatrin peptide

Sequence: GLSKGCFGLKLDRIGSMSGLGCNSFRY

Modifications: disulfide,

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP has a marked inhibitory effect on the proliferation of human VSMCs derived from both IMA and SV, which gives it a potential advantage in the therapy of restenosis after CABG. The anti-mitogenic effect appears to be mediated  via  the particulate guanylyl cyclase-coupled receptor by increasing the intracellular cyclic GMP. 

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

PLoS ONE. 6(5)e20477.Federation for Clinical Research. 2009 Jan; 57(1)18-21.

Biological Chemistry. 2008 Dec 12; 283(50)35003-35009

J Clin Invest. 1993 Oct ;92(4):2048-52.

The Journal of Clinical Investigation. Oct 1993; 92(4)2048.