Product name: Thyrotropin-releasing hormone

Synonyms: TRH,Protirelin,TSH-releasing factor,Thyroliberin,Thyrotropin-releasing factor,TRF,

Sequence: Pyr-His-Pro-NH2

Modifications: n-terminal Pyr,c-terminal amide,

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Thyrotropin-releasing hormone (TRH) is a classical hormone that controls thyroid hormone production in the anterior pituitary gland.TRH and its analogs have been reported to modulate descending monoaminergic inhibitory neurons, resulting in antinociception.
Thyrotropin-releasing hormone (TRH) is the first hypothalamic hypophysiotropic neuropeptide whose sequence has been chemically characterized. The primary structure of TRH (pGlu-His-Pro-NH(2)) has been fully conserved across the vertebrate phylum.In amphibians, TRH is a marginal stimulator of TSH release in adult frogs, not in tadpoles, and a major releasing factor for GH and PRL. In birds, TRH triggers TSH and GH secretion. In mammals, TRH stimulates TSH, GH and PRL release. In fish and amphibians, TRH is also a very potent stimulator of alpha-melanocyte-stimulating hormone release.The occurrence of large amounts of TRH in the frog skin and high concentrations of TRH in frog plasma suggests that, in amphibians, skin-derived TRH may exert hypophysiotropic functions.

Uniprot ID: P20396

Usage: For Scientific Research Use Only, Not for Human Use.

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Journal of Surgical Research, Volume 189, Issue 2, 15 June 2014, Pages 359-365

Neuroscience, Volume 247, 5 September 2013, Pages 43-54

Neuroscience, Volume 199, 29 December 2011, Pages 74-85

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Frontiers in Neuroendocrinology, Volume 31, Issue 2, April 2010, Pages 134-156

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